Gathering limits at homes and outdoors have been scrapped.
Masks will no longer be required indoors – except in retail settings, and venues will be allowed to operate at full capacity.
The easing of restrictions means large-scale events such as the upcoming Boxing Day Test at the MCG will be able to go ahead with a full crowd of 100,000 vaccinated attendees.
“Because 90 per cent of Victorians have gone and gotten vaccinated, so many of these rules – almost all of them can fall away,” Mr Andrews said.